Across TCGA pan-cancer cohorts, VAC14-AS1 RNA is linked to patient survival in 18 of 34 cancer types, making it the most broadly survival-associated VAC14-AS1 data layer.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where higher VAC14-AS1 RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated VAC14-AS1 expression acts as an unfavorable survival marker, although some lineages such as COAD and THCA show a favorable association.

KIRC, UVM, and MESO are the cancer types where VAC14-AS1 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
KIRC	DFS	Median	All	0.486	0.747	<.001	146	view →
UVM	DFS	Tertile	III,IV	0.302	0.764	.002	69	view →
MESO	OS	Median	All	0.426	0.639	.002	46	view →
SARC	DFS	Median	All	0.425	0.596	<.001	35	view →
COAD	DFS	Tertile	IV	0.552	0.296	.010	35	view →
LGG	OS	Median	All	0.753	0.857	.001	31	view →
THCA	DFS	Quartile	All	1.000	0.755	.004	28	view →
READ	DFS	Median	IV	0.936	0.179	.010	19	view →
SKCM	DFS	Tertile	All	0.634	0.816	.005	18	view →
GBM	DFS	Tertile	All	0.195	0.328	.006	18	view →
DLBC	DFS	Tertile	All	0.937	0.621	.025	8	view →
KIRP	DFS	Median	All	0.802	0.908	.003	6	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 18 lineages.

Exploration

Same gene, other analysis: VAC14-AS1 tumor-vs-normal RNA expression · all VAC14-AS1 data types