UXT

Across TCGA patient cohorts, UXT mutation is significantly associated with the RNA expression of many other genes, with 1,950 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible UXT-associated genes across cancer lineages are MIR1266, HSPE1-MOB4, and ARMCX5-GPRASP2. Each is linked with UXT in more than 1 cancer types. Because this analysis shows association rather than direction, both UXT-to-partner and partner-to-UXT results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MIR1266 grouped by UXT-low versus UXT-high in CESC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (UXT→partner) and Y-score (partner→UXT) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CESC	MIR1266 →	+0.446	+5.969	<.001	.002	3	2
UCEC	HSPE1-MOB4 →	+0.234	+2.951	<.001	<.001	3	1
UCEC	ARMCX5-GPRASP2 →	+0.422	+3.354	.006	.005	3	1
UCEC	RNU6-6P →	+0.584	+2.549	<.001	.001	3	1
UCEC	POM121C →	+0.520	+2.638	<.001	.005	3	1
UCEC	INO80B-WBP1 →	+0.166	+2.992	<.001	.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,950 associations by consensus.

MIR1266 by UXT expression — CESC

Explore this box plot interactively →