UXT

Across TCGA patient cohorts, UXT mutation is significantly associated with the total protein of many other genes, with 11 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible UXT-associated genes across cancer lineages are ERK2, PAI-1, and PDCD4. Each is linked with UXT in more than 1 cancer types. Because this analysis shows association rather than direction, both UXT-to-partner and partner-to-UXT results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ERK2 grouped by UXT-low versus UXT-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (UXT→partner) and Y-score (partner→UXT) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ERK2 →	+0.209	+3.000	.030	.036	3	1
UCEC	PAI-1 →	+0.351	+3.169	.041	.019	3	1
UCEC	PDCD4 →	-0.771	-2.321	.001	.035	3	1
UCEC	STAT3_pY705 →	-0.480	-2.321	<.001	.035	3	1
UCEC	ATM →	-0.478	-2.321	.036	.035	3	1
UCEC	p62 Lck ligand →	+0.419	+2.321	.010	.035	2	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 11 associations by consensus.

ERK2 by UXT expression — UCEC

Explore this box plot interactively →