UXT

Across TCGA cell cohorts, UXT RNA expression is significantly associated with the go_rna of many other GO terms, with 2,738 significant associations in total. SOFT_TISSUE shows the largest number of these associations.

The most reproducible UXT-associated GO terms across cancer lineages are Negative regulation of nuclear-transcribed mRNA catabolic process, nonsense-mediated decay, Positive regulation of protein import into nucleus, and Establishment or maintenance of epithelial cell apical/basal polarity. Each is linked with UXT in more than 9 cancer types. Because this analysis shows association rather than direction, both UXT-to-partner and partner-to-UXT results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Negative regulation of nuclear-transcribed mRNA catabolic process, nonsense-mediated decay grouped by UXT-low versus UXT-high in SOFT_TISSUE.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (UXT→partner) and Y-score (partner→UXT) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SOFT_TISSUE	Negative regulation of nuclear-transcribed mRNA catabolic process, nonsense-mediated decay →	-0.093	-0.719	<.001	<.001	3	9
CNS	Positive regulation of protein import into nucleus →	-0.077	-0.542	<.001	.006	3	9
OESOPHAGUS	Establishment or maintenance of epithelial cell apical/basal polarity →	-0.119	-0.927	.003	.001	2	10
SOFT_TISSUE	miRNA processing →	-0.079	-0.510	<.001	.001	3	9
PANCREAS	rDNA heterochromatin formation →	+0.085	+0.804	.001	<.001	3	8
LARGE_INTESTINE	Negative regulation of mRNA catabolic process →	-0.049	-0.663	.002	<.001	3	8

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,738 associations by consensus.

Negative regulation of nuclear-transcribed mRNA catabolic process, nonsense-mediated decay by UXT expression — SOFT_TISSUE

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