UXS1

Across TCGA pan-cancer cohorts, UXS1 mass-spec protein differs between tumor and matched normal tissue in 4 of 18 cancer types tested, making tumor–normal expression one of UXS1’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where UXS1 mass-spec protein is more highly expressed in tumor relative to normal tissue. In most cancer types UXS1 is over-expressed in tumor, although a few such as CCRCC and LSCC show the opposite, repressed pattern.

HNSC, COAD, and CCRCC are the cancer types where UXS1 tumor–normal differential expression is most reproducible.

mass-spec protein tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in UXS1 mass-spec protein (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	All	III,IV	+0.300	<.001	11	view →
COAD	Male	III,IV	+0.566	<.001	10	view →
CCRCC	Male	III,IV	−0.447	<.001	6	view →
LSCC	All	All	−0.119	.003	3	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 4 strongest of 4 lineages.

UXS1–HNSC

Open the HNSC breakdown →