UXS1

Across TCGA patient cohorts, UXS1 mutation is significantly associated with the RNA expression of many other genes, with 4,078 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible UXS1-associated genes across cancer lineages are TRDJ2, RPL21P90, and NF1P10. Each is linked with UXS1 in more than 1 cancer types. Because this analysis shows association rather than direction, both UXS1-to-partner and partner-to-UXS1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, TRDJ2 grouped by UXS1-low versus UXS1-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (UXS1→partner) and Y-score (partner→UXS1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	TRDJ2 →	+0.387	+2.915	.008	.008	3	2
SKCM	RPL21P90 →	+0.183	+3.772	.003	.003	3	2
CESC	NF1P10 →	+0.390	+7.154	<.001	<.001	3	2
UCEC	CCDC82 →	+0.407	+2.534	.007	<.001	3	2
UCEC	CHEK1 →	+0.585	+3.606	.001	.001	3	2
UCEC	TEX30 →	+0.599	+3.095	<.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,078 associations by consensus.

TRDJ2 by UXS1 expression — SKCM

Explore this box plot interactively →