UVSSA

Across TCGA pan-cancer cohorts, UVSSA mass-spec protein is linked to patient survival in 5 of 34 cancer types, making it a survival-associated UVSSA data layer compared with 25 for mass-spec protein and 8 for mutation status.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher UVSSA mass-spec protein is associated with worse disease-free survival. In most high-consensus cancer types, elevated UVSSA expression acts as an unfavorable survival marker, although some lineages such as CCRCC and LUAD show a favorable association.

HNSC, GBM, and CCRCC are the cancer types where UVSSA mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	DFS	Median	III,IV	0.900	1.000	.006	17	view →
GBM	DFS	Median	All	0.190	0.589	<.001	16	view →
CCRCC	DFS	Median	All	0.978	0.854	.008	12	view →
LUAD	DFS	Quartile	II,III,IV	1.000	0.245	.017	5	view →
LSCC	DFS	Median	All	0.905	1.000	.048	1	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

UVSSA–HNSC (DFS)

Open the HNSC breakdown →