UVSSA

Across TCGA patient cohorts, UVSSA mutation is significantly associated with the RNA expression of many other genes, with 1,401 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible UVSSA-associated genes across cancer lineages are TRBV14, TRAC, and GTSF1L. Each is linked with UVSSA in more than 1 cancer types. Because this analysis shows association rather than direction, both UVSSA-to-partner and partner-to-UVSSA results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, TRBV14 grouped by UVSSA-low versus UVSSA-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (UVSSA→partner) and Y-score (partner→UVSSA) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	TRBV14 →	+0.298	+2.017	.003	.002	3	2
UCEC	TRAC →	+0.932	+2.000	.001	.009	3	2
COAD	GTSF1L →	+0.172	+3.527	.004	.007	3	2
UCEC	CYTH4 →	+0.497	+1.818	.004	.002	3	2
UCEC	GZMB →	+1.376	+4.169	<.001	<.001	3	2
UCEC	TLR8 →	+0.366	+1.939	.007	.009	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,401 associations by consensus.

TRBV14 by UVSSA expression — UCEC

Explore this box plot interactively →