UVSSA

Across TCGA patient cohorts, UVSSA mutation is significantly associated with the total protein of many other genes, with 36 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible UVSSA-associated genes across cancer lineages are 14-3-3_beta, A-Raf_pS299, and ERK2. Each is linked with UVSSA in more than 1 cancer types. Because this analysis shows association rather than direction, both UVSSA-to-partner and partner-to-UVSSA results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, 14-3-3_beta grouped by UVSSA-low versus UVSSA-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (UVSSA→partner) and Y-score (partner→UVSSA) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	14-3-3_beta →	-0.071	-2.432	.049	.018	3	2
UCEC	A-Raf_pS299 →	-0.157	-1.584	<.001	.019	3	2
UCEC	ERK2 →	+0.151	+1.874	.030	.049	3	2
UCEC	PCNA →	+0.265	+2.321	<.001	.001	3	2
UCEC	STAT3_pY705 →	-0.313	-1.405	<.001	.043	3	2
UCEC	AR →	-0.417	-2.321	.001	.005	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 36 associations by consensus.

14-3-3_beta by UVSSA expression — UCEC

Explore this box plot interactively →