UVSSA

Across TCGA cell cohorts, UVSSA mutation is significantly associated with the RNA expression of many other genes, with 51 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible UVSSA-associated genes across cancer lineages are NPBWR2, FTMT, and CLEC4G. Each is linked with UVSSA in more than 1 cancer types. Because this analysis shows association rather than direction, both UVSSA-to-partner and partner-to-UVSSA results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, NPBWR2 grouped by UVSSA-low versus UVSSA-high in SOFT_TISSUE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (UVSSA→partner) and Y-score (partner→UVSSA) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SOFT_TISSUE	NPBWR2 →	+0.023	+4.882	<.001	.001	3	1
SOFT_TISSUE	FTMT →	+0.065	+4.977	<.001	.002	3	1
SOFT_TISSUE	CLEC4G →	+0.057	+4.635	<.001	.003	3	1
LUNG_NSCLC_LUAD	NANOGNB →	+0.135	+4.887	<.001	.009	3	1
BLOOD_Leukemia	BSND →	+0.010	+4.551	.003	.004	3	1
LARGE_INTESTINE	PKD2L1 →	+0.165	+2.974	<.001	<.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 51 associations by consensus.

NPBWR2 by UVSSA expression — SOFT_TISSUE

Explore this box plot interactively →