UTP4

Across TCGA patient cohorts, UTP4 mutation is significantly associated with the total protein of many other genes, with 28 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible UTP4-associated genes across cancer lineages are PCNA, ASNS, and Caspase-7-cleavedD198. Each is linked with UTP4 in more than 1 cancer types. Because this analysis shows association rather than direction, both UTP4-to-partner and partner-to-UTP4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PCNA grouped by UTP4-low versus UTP4-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (UTP4→partner) and Y-score (partner→UTP4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	PCNA →	+0.184	+2.584	.015	.010	3	2
UCEC	ASNS →	+0.360	+2.459	.004	.018	3	2
UCEC	Caspase-7-cleavedD198 →	+0.615	+1.341	.003	.043	3	2
UCEC	C-Raf →	+0.146	+1.700	.003	.042	3	2
UCEC	ERK2 →	+0.145	+2.321	.033	.033	3	1
UCEC	JNK_pT183_Y185 →	-0.136	-1.349	.021	.037	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 28 associations by consensus.

PCNA by UTP4 expression — UCEC

Explore this box plot interactively →