UTP25

Across TCGA pan-cancer cohorts, UTP25 mass-spec protein is linked to patient survival in 7 of 34 cancer types, making it a survival-associated UTP25 data layer compared with 26 for mass-spec protein and 5 for mutation status.

The strongest signal is observed in clear cell renal cell carcinoma (CCRCC), where higher UTP25 mass-spec protein is associated with worse overall survival. In most high-consensus cancer types, elevated UTP25 expression acts as an unfavorable survival marker, although some lineages such as LUAD and UCEC show a favorable association.

CCRCC, LUAD, and HNSC are the cancer types where UTP25 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
CCRCC	OS	Quartile	III,IV	0.416	0.887	<.001	36	view →
LUAD	OS	Quartile	III,IV	0.990	0.421	.026	9	view →
HNSC	DFS	Quartile	IV	0.655	0.920	.022	6	view →
UCEC	OS	Tertile	III,IV	0.847	0.285	.041	4	view →
PDAC	DFS	Tertile	IV	0.550	0.217	.024	3	view →
LSCC	DFS	Median	II,III,IV	0.820	0.554	.028	3	view →
GBM	OS	Tertile	All	0.619	0.349	.042	2	view →

Pink = unfavorable, green = favorable. Showing the 7 strongest of 7 lineages.

UTP25–CCRCC (OS)

Open the CCRCC breakdown →