UTP25

Across TCGA patient cohorts, UTP25 mutation is significantly associated with the total protein of many other genes, with 27 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible UTP25-associated genes across cancer lineages are ATM, Notch1, and 4E-BP1_pT37_T46. Each is linked with UTP25 in more than 2 cancer types. Because this analysis shows association rather than direction, both UTP25-to-partner and partner-to-UTP25 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ATM grouped by UTP25-low versus UTP25-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (UTP25→partner) and Y-score (partner→UTP25) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ATM →	-0.554	-2.794	<.001	.002	3	3
UCEC	Notch1 →	+0.102	+1.584	.020	.005	3	2
UCEC	4E-BP1_pT37_T46 →	-0.261	-1.571	.027	.032	3	2
UCEC	Caspase-8 →	-0.227	-2.710	.004	<.001	3	2
UCEC	eIF4E →	+0.186	+3.820	.005	<.001	3	1
UCEC	ERK2 →	+0.188	+2.087	.001	.004	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 27 associations by consensus.

ATM by UTP25 expression — UCEC

Explore this box plot interactively →