UTP23

Across TCGA patient cohorts, UTP23 mutation is significantly associated with the total protein of many other genes, with 14 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible UTP23-associated genes across cancer lineages are JNK2, Notch1, and PDCD4. Each is linked with UTP23 in more than 1 cancer types. Because this analysis shows association rather than direction, both UTP23-to-partner and partner-to-UTP23 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, JNK2 grouped by UTP23-low versus UTP23-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (UTP23→partner) and Y-score (partner→UTP23) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	JNK2 →	+0.302	+3.026	.002	.018	3	1
UCEC	Notch1 →	+0.154	+3.009	.029	.019	3	1
UCEC	PDCD4 →	-0.647	-2.321	.006	.035	3	1
UCEC	PKC-b-II_pS660 →	-0.333	-3.459	.016	.005	3	1
UCEC	STAT3_pY705 →	-0.440	-2.321	<.001	.035	3	1
UCEC	Stathmin →	+0.149	+2.833	.031	.034	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 14 associations by consensus.

JNK2 by UTP23 expression — UCEC

Explore this box plot interactively →