UTP18

Across TCGA patient cohorts, UTP18 mutation is significantly associated with the total protein of many other genes, with 7 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible UTP18-associated genes across cancer lineages are TFRC, Caspase-7-cleavedD198, and Shc_pY317. Each is linked with UTP18 in more than 1 cancer types. Because this analysis shows association rather than direction, both UTP18-to-partner and partner-to-UTP18 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, TFRC grouped by UTP18-low versus UTP18-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (UTP18→partner) and Y-score (partner→UTP18) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	TFRC →	+0.663	+3.169	.022	.020	3	2
UCEC	Caspase-7-cleavedD198 →	+0.761	+2.827	.019	.035	3	1
UCEC	Shc_pY317 →	-0.255	-3.169	.002	.020	2	1
UCEC	EGFR_pY1068 →	-0.377	-3.169	.006	.020	1	1
UCEC	STAT3_pY705 →	-0.465	-3.169	.001	.020	1	1
UCEC	BRD4 →	+0.387	+2.814	.018	.036	1	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 7 associations by consensus.

TFRC by UTP18 expression — UCEC

Explore this box plot interactively →