UTP14A

Across TCGA pan-cancer cohorts, UTP14A mass-spec protein is linked to patient survival in 8 of 34 cancer types, making it a survival-associated UTP14A data layer compared with 24 for mass-spec protein and 5 for mutation status.

The strongest signal is observed in clear cell renal cell carcinoma (CCRCC), where higher UTP14A mass-spec protein is associated with worse overall survival. In most high-consensus cancer types, elevated UTP14A expression acts as an unfavorable survival marker, although some lineages such as COAD and LSCC show a favorable association.

CCRCC, LUAD, and COAD are the cancer types where UTP14A mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
CCRCC	OS	Quartile	III,IV	0.335	0.802	.009	31	view →
LUAD	DFS	Median	II,III,IV	0.217	0.909	<.001	20	view →
COAD	DFS	Median	All	1.000	0.898	.041	12	view →
LSCC	DFS	Tertile	II,III,IV	0.838	0.457	.020	8	view →
HNSC	DFS	Tertile	IV	0.562	0.869	.006	7	view →
OV	DFS	Quartile	All	0.594	0.884	.049	4	view →
GBM	OS	Tertile	All	0.506	0.295	.024	2	view →
PDAC	OS	Median	All	0.726	0.908	.041	1	view →

Pink = unfavorable, green = favorable. Showing the 8 strongest of 8 lineages.

UTP14A–CCRCC (OS)

Open the CCRCC breakdown →