UST

Across TCGA pan-cancer cohorts, UST Mutation is linked to patient survival in 6 of 34 cancer types, making it a survival-associated UST data layer compared with 20 for mass-spec protein and 3 for mass-spec protein.

The strongest signal is observed in cervical squamous cell carcinoma and endocervical adenocarcinoma (CESC), where higher UST Mutation is associated with worse disease-free survival. In most high-consensus cancer types, elevated UST expression acts as an unfavorable survival marker.

CESC, LUAD, and COAD are the cancer types where UST Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
CESC	DFS	Median	II,III,IV	0.053	0.786	<.001	38	view →
LUAD	OS	Median	III,IV	0.223	0.677	.006	15	view →
COAD	DFS	Median	All	0.114	0.559	.006	12	view →
UCEC	OS	Median	IV	0.231	0.592	.036	6	view →
READ	OS	Median	III,IV	0.328	0.751	.003	3	view →
LIHC	OS	Median	II,III,IV	0.152	0.614	.049	3	view →

Pink = unfavorable, green = favorable. Showing the 6 strongest of 6 lineages.

UST–CESC (DFS)

Open the CESC breakdown →