UST

Across TCGA pan-cancer cohorts, UST mass-spec protein is linked to patient survival in 3 of 34 cancer types, making it a survival-associated UST data layer compared with 20 for mass-spec protein and 6 for mutation status.

The strongest signal is observed in lung squamous cell carcinoma (LSCC), where higher UST mass-spec protein is associated with better disease-free survival. In most high-consensus cancer types, elevated UST expression acts as an unfavorable survival marker, although some lineages such as LSCC and PDAC show a favorable association.

LSCC, PDAC, and GBM are the cancer types where UST mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LSCC	DFS	Tertile	All	0.903	0.382	<.001	65	view →
PDAC	DFS	Median	All	0.960	0.518	.031	4	view →
GBM	OS	Quartile	All	0.817	0.421	.014	2	view →

Pink = unfavorable, green = favorable. Showing the 3 strongest of 3 lineages.

UST–LSCC (DFS)

Open the LSCC breakdown →