UST-AS2

Across TCGA pan-cancer cohorts, UST-AS2 RNA is linked to patient survival in 21 of 34 cancer types, making it the most broadly survival-associated UST-AS2 data layer.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where higher UST-AS2 RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated UST-AS2 expression acts as an unfavorable survival marker, although some lineages such as SKCM and LUAD show a favorable association.

KIRC, KICH, and SKCM are the cancer types where UST-AS2 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
KIRC	DFS	Median	All	0.521	0.715	<.001	129	view →
KICH	DFS	Quartile	All	0.551	0.915	<.001	102	view →
SKCM	OS	Median	II,III,IV	0.380	0.252	<.001	84	view →
UVM	OS	Tertile	III,IV	0.359	0.790	.010	55	view →
LUAD	OS	Quartile	II,III,IV	0.703	0.446	.001	53	view →
LGG	OS	Median	All	0.364	0.516	<.001	50	view →
ESCA	DFS	Tertile	III,IV	0.593	0.278	.002	30	view →
LUSC	DFS	Quartile	II,III,IV	0.241	0.547	.005	23	view →
ACC	DFS	Tertile	II,III,IV	0.734	0.222	.001	20	view →
SARC	DFS	Quartile	All	0.201	0.472	.001	19	view →
MESO	OS	Quartile	IV	0.122	0.801	.006	15	view →
HNSC	OS	Median	All	0.804	0.727	.012	12	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 21 lineages.

UST-AS2–KIRC (DFS)

Open the KIRC breakdown →