USPL1

Across TCGA patient cohorts, USPL1 mutation is significantly associated with the RNA expression of many other genes, with 2,989 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible USPL1-associated genes across cancer lineages are ATF4, PHBP7, and CYP4F36P. Each is linked with USPL1 in more than 2 cancer types. Because this analysis shows association rather than direction, both USPL1-to-partner and partner-to-USPL1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ATF4 grouped by USPL1-low versus USPL1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (USPL1→partner) and Y-score (partner→USPL1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ATF4 →	+0.478	+2.305	<.001	<.001	3	3
BLCA	PHBP7 →	+0.090	+3.028	.001	.005	3	3
BLCA	CYP4F36P →	+0.470	+3.388	<.001	.001	3	2
UCEC	RNA5SP420 →	+0.425	+1.645	<.001	.003	3	2
READ	RN7SL25P →	+0.308	+5.925	<.001	.002	3	2
BRCA	MORF4L2P1 →	+0.064	+2.926	.001	.006	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,989 associations by consensus.

ATF4 by USPL1 expression — UCEC

Explore this box plot interactively →