USPL1

Across TCGA cell cohorts, USPL1 mutation is significantly associated with the RNA expression of many other genes, with 70 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible USPL1-associated genes across cancer lineages are FCRL4, GSTA3, and PRSS48. Each is linked with USPL1 in more than 1 cancer types. Because this analysis shows association rather than direction, both USPL1-to-partner and partner-to-USPL1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, FCRL4 grouped by USPL1-low versus USPL1-high in LUNG_NSCLC_LUSC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (USPL1→partner) and Y-score (partner→USPL1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUSC	FCRL4 →	+0.012	+4.108	<.001	.005	3	2
LUNG_NSCLC_LUSC	GSTA3 →	+0.058	+4.108	<.001	.005	3	2
LUNG_NSCLC_LUSC	PRSS48 →	+0.089	+4.108	<.001	.005	3	2
BLOOD_Leukemia	OR7A10 →	+0.008	+4.984	<.001	.002	3	2
BLOOD_Leukemia	APOL5 →	+0.022	+4.060	<.001	.003	3	2
BLOOD_Leukemia	OR10H3 →	+0.014	+4.984	<.001	.002	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 70 associations by consensus.

FCRL4 by USPL1 expression — LUNG_NSCLC_LUSC

Explore this box plot interactively →