Across TCGA pan-cancer cohorts, USP9YP22 RNA differs between tumor and matched normal tissue in 2 of 18 cancer types tested, making tumor–normal expression one of USP9YP22’s most consistent transcriptional readouts.
The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where USP9YP22 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types USP9YP22 is over-expressed in tumor, although a few such as PRAD show the opposite, repressed pattern.
KIRC and PRAD are the cancer types where USP9YP22 tumor–normal differential expression is most reproducible.