Across TCGA pan-cancer cohorts, USP9YP14 RNA differs between tumor and matched normal tissue in 2 of 18 cancer types tested, making tumor–normal expression one of USP9YP14’s most consistent transcriptional readouts.
The strongest signal is observed in breast invasive carcinoma (BRCA), where USP9YP14 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types USP9YP14 is over-expressed in tumor, although a few such as STAD show the opposite, repressed pattern.
BRCA and STAD are the cancer types where USP9YP14 tumor–normal differential expression is most reproducible.