USP53

Across TCGA pan-cancer cohorts, USP53 mass-spec protein is linked to patient survival in 4 of 34 cancer types, making it a survival-associated USP53 data layer compared with 26 for mass-spec protein and 7 for mutation status.

The strongest signal is observed in clear cell renal cell carcinoma (CCRCC), where higher USP53 mass-spec protein is associated with worse disease-free survival. In most high-consensus cancer types, elevated USP53 expression acts as an unfavorable survival marker, although some lineages such as PDAC and LUAD show a favorable association.

CCRCC, PDAC, and LUAD are the cancer types where USP53 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
CCRCC	DFS	Median	III,IV	0.105	0.904	.008	20	view →
PDAC	DFS	Median	III,IV	0.588	0.214	<.001	20	view →
LUAD	DFS	Median	All	0.833	0.504	.018	3	view →
LSCC	DFS	Quartile	All	1.000	0.892	.040	1	view →

Pink = unfavorable, green = favorable. Showing the 4 strongest of 4 lineages.

USP53–CCRCC (DFS)

Open the CCRCC breakdown →