USP53

Across TCGA patient cohorts, USP53 mutation is significantly associated with the total protein of many other genes, with 43 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible USP53-associated genes across cancer lineages are ATM, eIF4E, and Ku80. Each is linked with USP53 in more than 2 cancer types. Because this analysis shows association rather than direction, both USP53-to-partner and partner-to-USP53 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ATM grouped by USP53-low versus USP53-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (USP53→partner) and Y-score (partner→USP53) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ATM →	-0.342	-1.415	.044	.046	3	3
UCEC	eIF4E →	+0.168	+2.169	.033	.003	3	2
UCEC	Ku80 →	+0.189	+2.183	.033	.001	3	2
UCEC	MEK1 →	+0.402	+2.662	.003	<.001	3	2
UCEC	MIG-6 →	+0.077	+1.428	.038	.029	3	2
UCEC	Annexin_VII →	-0.128	-2.662	.014	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 43 associations by consensus.

ATM by USP53 expression — UCEC

Explore this box plot interactively →