USP53

Across TCGA cell cohorts, USP53 RNA expression is significantly associated with the go_rna of many other GO terms, with 3,996 significant associations in total. BONE shows the largest number of these associations.

The most reproducible USP53-associated GO terms across cancer lineages are Establishment of endothelial intestinal barrier, Adherens junction maintenance, and Protein modification by small protein removal. Each is linked with USP53 in more than 12 cancer types. Because this analysis shows association rather than direction, both USP53-to-partner and partner-to-USP53 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Establishment of endothelial intestinal barrier grouped by USP53-low versus USP53-high in STOMACH.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (USP53→partner) and Y-score (partner→USP53) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STOMACH	Establishment of endothelial intestinal barrier →	+0.187	+1.390	<.001	<.001	3	13
BONE	Adherens junction maintenance →	+0.278	+1.422	<.001	<.001	3	11
SOFT_TISSUE	Protein modification by small protein removal →	+0.047	+1.160	<.001	<.001	3	10
PANCREAS	Multivesicular body assembly →	+0.099	+1.200	<.001	<.001	3	10
STOMACH	Vacuolar transport →	+0.082	+1.618	.001	<.001	3	10
STOMACH	Establishment of protein localization to vacuole →	+0.076	+1.170	<.001	.004	3	10

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,996 associations by consensus.

Establishment of endothelial intestinal barrier by USP53 expression — STOMACH

Explore this box plot interactively →