USP53

Across TCGA cell cohorts, USP53 mutation is significantly associated with the RNA expression of many other genes, with 126 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible USP53-associated genes across cancer lineages are TAAR2, TAAR6, and KLF18. Each is linked with USP53 in more than 1 cancer types. Because this analysis shows association rather than direction, both USP53-to-partner and partner-to-USP53 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, TAAR2 grouped by USP53-low versus USP53-high in STOMACH.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (USP53→partner) and Y-score (partner→USP53) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STOMACH	TAAR2 →	+0.015	+4.285	<.001	.007	3	1
STOMACH	TAAR6 →	+0.021	+4.794	<.001	.001	3	1
STOMACH	KLF18 →	+0.005	+4.285	<.001	.007	3	1
LARGE_INTESTINE	TFR2 →	+1.222	+3.364	.002	.002	3	1
LARGE_INTESTINE	USP46 →	+0.773	+3.451	<.001	.002	3	1
LARGE_INTESTINE	KLHL2 →	+0.729	+3.169	.001	.009	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 126 associations by consensus.

TAAR2 by USP53 expression — STOMACH

Explore this box plot interactively →