USP50

Across TCGA pan-cancer cohorts, USP50 Mutation is linked to patient survival in 4 of 34 cancer types, making it a survival-associated USP50 data layer compared with 19 for mass-spec protein.

The strongest signal is observed in uterine corpus endometrial carcinoma (UCEC), where higher USP50 Mutation is associated with better disease-free survival. In most high-consensus cancer types, elevated USP50 expression acts as an unfavorable survival marker, although some lineages such as UCEC show a favorable association.

UCEC, COAD, and LUSC are the cancer types where USP50 Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UCEC	DFS	Median	II,III,IV	1.000	0.439	.017	28	view →
COAD	OS	Median	IV	0.056	0.649	<.001	16	view →
LUSC	OS	Median	All	0.211	0.676	.009	12	view →
SKCM	OS	Median	All	0.249	0.781	.011	12	view →

Pink = unfavorable, green = favorable. Showing the 4 strongest of 4 lineages.

USP50–UCEC (DFS)

Open the UCEC breakdown →