USP50

Across TCGA patient cohorts, USP50 mutation is significantly associated with the total protein of many other genes, with 42 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible USP50-associated genes across cancer lineages are Caspase-7-cleavedD198, C-Raf, and A-Raf_pS299. Each is linked with USP50 in more than 1 cancer types. Because this analysis shows association rather than direction, both USP50-to-partner and partner-to-USP50 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Caspase-7-cleavedD198 grouped by USP50-low versus USP50-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (USP50→partner) and Y-score (partner→USP50) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Caspase-7-cleavedD198 →	+0.531	+2.000	.047	.032	3	2
UCEC	C-Raf →	+0.275	+2.000	<.001	.030	3	2
UCEC	A-Raf_pS299 →	-0.184	-3.000	<.001	.036	3	1
UCEC	FASN →	+0.592	+3.807	<.001	<.001	2	2
UCEC	FoxM1 →	+0.442	+3.807	<.001	<.001	3	1
UCEC	FOXO3a_pS318_S321 →	-0.129	-3.449	.021	.005	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 42 associations by consensus.

Caspase-7-cleavedD198 by USP50 expression — UCEC

Explore this box plot interactively →