USP50

Across TCGA cell cohorts, USP50 mutation is significantly associated with the RNA expression of many other genes, with 3 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible USP50-associated genes across cancer lineages are TNP1, USP17L20, and TMEM114. Each is linked with USP50 in more than 1 cancer types. Because this analysis shows association rather than direction, both USP50-to-partner and partner-to-USP50 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, TNP1 grouped by USP50-low versus USP50-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (USP50→partner) and Y-score (partner→USP50) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	TNP1 →	+0.172	+5.415	<.001	.004	3	1
LARGE_INTESTINE	USP17L20 →	+0.006	+4.977	<.001	.007	3	1
SKIN	TMEM114 →	+0.051	+4.977	<.001	.007	3	1

Each partner links to its Q-omics profile. Showing the 3 strongest of 3 associations by consensus.

TNP1 by USP50 expression — LARGE_INTESTINE

Explore this box plot interactively →