USP5

Across TCGA pan-cancer cohorts, USP5 mass-spec protein is linked to patient survival in 4 of 34 cancer types, making it a survival-associated USP5 data layer compared with 24 for mass-spec protein and 5 for mutation status.

The strongest signal is observed in pancreatic ductal adenocarcinoma (PDAC), where higher USP5 mass-spec protein is associated with better disease-free survival. In most high-consensus cancer types, elevated USP5 expression acts as an unfavorable survival marker, although some lineages such as PDAC show a favorable association.

PDAC, LUAD, and CCRCC are the cancer types where USP5 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
PDAC	DFS	Quartile	All	0.596	0.249	.006	18	view →
LUAD	OS	Quartile	All	0.486	0.870	.007	16	view →
CCRCC	DFS	Median	All	0.637	0.831	.025	6	view →
LSCC	DFS	Median	All	0.601	0.876	.036	1	view →

Pink = unfavorable, green = favorable. Showing the 4 strongest of 4 lineages.

USP5–PDAC (DFS)

Open the PDAC breakdown →