USP5

Across TCGA patient cohorts, USP5 mutation is significantly associated with the total protein of many other genes, with 34 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible USP5-associated genes across cancer lineages are ASNS, JNK2, and MEK1. Each is linked with USP5 in more than 2 cancer types. Because this analysis shows association rather than direction, both USP5-to-partner and partner-to-USP5 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ASNS grouped by USP5-low versus USP5-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (USP5→partner) and Y-score (partner→USP5) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ASNS →	+0.446	+2.169	<.001	.003	3	3
UCEC	JNK2 →	+0.242	+1.459	<.001	.012	3	2
UCEC	MEK1 →	+0.450	+2.321	<.001	<.001	3	2
UCEC	PCNA →	+0.151	+1.415	.031	.043	3	2
COAD	PDCD4 →	-0.505	-2.991	.020	.036	3	2
UCEC	Shc_pY317 →	-0.131	-1.459	.007	.012	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 34 associations by consensus.

ASNS by USP5 expression — UCEC

Explore this box plot interactively →