USP5

Across TCGA cell cohorts, USP5 RNA expression is significantly associated with the go_rna of many other GO terms, with 3,799 significant associations in total. BLOOD_Lymphoma shows the largest number of these associations.

The most reproducible USP5-associated GO terms across cancer lineages are Spindle elongation, Positive regulation of mitotic cytokinesis, and Positive regulation of cytokinesis. Each is linked with USP5 in more than 16 cancer types. Because this analysis shows association rather than direction, both USP5-to-partner and partner-to-USP5 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Spindle elongation grouped by USP5-low versus USP5-high in URINARY_TRACT.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (USP5→partner) and Y-score (partner→USP5) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
URINARY_TRACT	Spindle elongation →	+0.264	+0.906	<.001	<.001	3	17
UPPER_AERODIGESTIVE_TRACT	Positive regulation of mitotic cytokinesis →	+0.145	+0.747	.002	.006	3	15
KIDNEY	Positive regulation of cytokinesis →	+0.107	+0.682	.001	.001	3	15
BONE	Mitotic nuclear division →	+0.124	+0.663	.009	.001	2	15
LARGE_INTESTINE	Regulation of nucleotide-excision repair →	+0.087	+0.728	<.001	<.001	3	14
SKIN	Positive regulation of mitotic cell cycle →	+0.072	+0.519	<.001	<.001	3	14

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,799 associations by consensus.

Spindle elongation by USP5 expression — URINARY_TRACT

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