USP5

Across TCGA cell cohorts, USP5 mutation is significantly associated with the drug of many other genes, with 18 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible USP5-associated genes across cancer lineages are Uprosertib, 630600, and Ispinesib Mesylate. Each is linked with USP5 in more than 1 cancer types. Because this analysis shows association rather than direction, both USP5-to-partner and partner-to-USP5 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Uprosertib grouped by USP5-low versus USP5-high in BLOOD_Leukemia.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (USP5→partner) and Y-score (partner→USP5) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	Uprosertib →	+0.513	+2.641	.020	.049	3	2
LARGE_INTESTINE	630600 →	+0.734	+2.649	.017	.046	3	1
LARGE_INTESTINE	Ispinesib Mesylate →	+0.800	+2.652	.013	.045	3	1
LARGE_INTESTINE	TL-2-105 →	+0.419	+2.652	.033	.045	3	1
LARGE_INTESTINE	TAK-715 →	+0.435	+2.786	.037	.037	3	1
LARGE_INTESTINE	CX-5461 →	+0.667	+2.652	.023	.045	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 18 associations by consensus.

Uprosertib by USP5 expression — BLOOD_Leukemia

Explore this box plot interactively →