USP49

Across TCGA pan-cancer cohorts, USP49 Mutation is linked to patient survival in 5 of 34 cancer types, making it a survival-associated USP49 data layer compared with 25 for mass-spec protein.

The strongest signal is observed in ovarian serous cystadenocarcinoma (OV), where higher USP49 Mutation is associated with worse overall survival. In most high-consensus cancer types, elevated USP49 expression acts as an unfavorable survival marker.

OV, COAD, and STAD are the cancer types where USP49 Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
OV	OS	Median	II,III,IV	0.022	0.844	<.001	36	view →
COAD	DFS	Median	III,IV	0.028	0.668	<.001	18	view →
STAD	OS	Median	IV	0.001	0.544	<.001	9	view →
UCEC	OS	Median	IV	0.231	0.592	.036	6	view →
GBM	DFS	Median	All	0.084	0.258	.038	3	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

USP49–OV (OS)

Open the OV breakdown →