USP49

Across TCGA patient cohorts, USP49 mutation is significantly associated with the total protein of many other genes, with 8 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible USP49-associated genes across cancer lineages are Caspase-7-cleavedD198, eIF4E, and MSH2. Each is linked with USP49 in more than 1 cancer types. Because this analysis shows association rather than direction, both USP49-to-partner and partner-to-USP49 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Caspase-7-cleavedD198 grouped by USP49-low versus USP49-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (USP49→partner) and Y-score (partner→USP49) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Caspase-7-cleavedD198 →	+0.842	+3.019	.002	.019	3	2
UCEC	eIF4E →	+0.201	+3.700	.041	.001	2	2
UCEC	MSH2 →	-0.365	-3.143	<.001	.018	3	1
UCEC	Notch1 →	+0.184	+2.820	.004	.035	3	1
UCEC	PCNA →	+0.279	+3.169	.005	.018	3	1
UCEC	Caspase-8 →	-0.248	-3.143	.034	.018	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 8 associations by consensus.

Caspase-7-cleavedD198 by USP49 expression — UCEC

Explore this box plot interactively →