USP48

Across TCGA pan-cancer cohorts, USP48 mass-spec protein is linked to patient survival in 5 of 34 cancer types, making it a survival-associated USP48 data layer compared with 26 for mass-spec protein and 6 for mutation status.

The strongest signal is observed in colon adenocarcinoma (COAD), where higher USP48 mass-spec protein is associated with worse disease-free survival. In most high-consensus cancer types, elevated USP48 expression acts as an unfavorable survival marker, although some lineages such as LSCC and PDAC show a favorable association.

COAD, UCEC, and HNSC are the cancer types where USP48 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
COAD	DFS	Median	II,III,IV	0.907	1.000	.008	30	view →
UCEC	DFS	Median	All	0.753	0.952	.001	14	view →
HNSC	DFS	Median	III,IV	0.908	0.993	.031	13	view →
LSCC	OS	Tertile	III,IV	0.918	0.525	.019	2	view →
PDAC	DFS	Tertile	III,IV	0.923	0.579	.048	1	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

USP48–COAD (DFS)

Open the COAD breakdown →