USP48

Across TCGA patient cohorts, USP48 mutation is significantly associated with the total protein of many other genes, with 44 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible USP48-associated genes across cancer lineages are ATM, E-Cadherin, and LKB1. Each is linked with USP48 in more than 2 cancer types. Because this analysis shows association rather than direction, both USP48-to-partner and partner-to-USP48 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ATM grouped by USP48-low versus USP48-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (USP48→partner) and Y-score (partner→USP48) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ATM →	-0.455	-2.571	.001	<.001	3	3
UCEC	E-Cadherin →	-0.306	-1.405	.040	.043	3	3
COAD	LKB1 →	+0.124	+2.824	.007	.034	3	2
UCEC	NDRG1_pT346 →	-0.359	-1.906	.016	.014	3	2
UCEC	PCNA →	+0.285	+3.807	<.001	<.001	3	2
UCEC	Rab25 →	-0.346	-1.584	<.001	.017	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 44 associations by consensus.

ATM by USP48 expression — UCEC

Explore this box plot interactively →