USP48

Across TCGA cell cohorts, USP48 mutation is significantly associated with the RNA expression of many other genes, with 10 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible USP48-associated genes across cancer lineages are ADIPOQ, OR2H1, and MMP27. Each is linked with USP48 in more than 1 cancer types. Because this analysis shows association rather than direction, both USP48-to-partner and partner-to-USP48 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ADIPOQ grouped by USP48-low versus USP48-high in LUNG_NSCLC_LUAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (USP48→partner) and Y-score (partner→USP48) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	ADIPOQ →	+0.029	+5.228	<.001	.005	3	1
OVARY	OR2H1 →	+0.027	+4.029	<.001	.009	3	1
BLOOD_Leukemia	MMP27 →	+0.019	+4.969	<.001	.003	3	1
BLOOD_Leukemia	KRTAP12-3 →	+0.061	+4.539	<.001	.007	3	1
BLOOD_Leukemia	TLE7 →	+0.034	+4.969	<.001	.003	3	1
LARGE_INTESTINE	BPIFA1 →	+0.149	+2.688	<.001	.008	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 10 associations by consensus.

ADIPOQ by USP48 expression — LUNG_NSCLC_LUAD

Explore this box plot interactively →