USP47

Across TCGA pan-cancer cohorts, USP47 Mutation is linked to patient survival in 5 of 34 cancer types, making it a survival-associated USP47 data layer compared with 21 for mass-spec protein and 3 for mass-spec protein.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher USP47 Mutation is associated with worse overall survival. In most high-consensus cancer types, elevated USP47 expression acts as an unfavorable survival marker, although some lineages such as UCEC show a favorable association.

HNSC, UCEC, and LUAD are the cancer types where USP47 Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	OS	Median	II,III,IV	0.087	0.756	<.001	27	view →
UCEC	DFS	Median	All	0.947	0.825	.012	24	view →
LUAD	OS	Median	All	0.004	0.835	<.001	18	view →
LGG	DFS	Median	All	0.250	0.753	.020	6	view →
ESCA	DFS	Median	All	0.238	0.537	.046	3	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

USP47–HNSC (OS)

Open the HNSC breakdown →