USP47

Across TCGA patient cohorts, USP47 mutation is significantly associated with the RNA expression of many other genes, with 4,314 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible USP47-associated genes across cancer lineages are CCDC7, CDK11B, and RIC8A. Each is linked with USP47 in more than 2 cancer types. Because this analysis shows association rather than direction, both USP47-to-partner and partner-to-USP47 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, CCDC7 grouped by USP47-low versus USP47-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (USP47→partner) and Y-score (partner→USP47) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	CCDC7 →	+0.269	+2.279	<.001	<.001	3	3
UCEC	CDK11B →	+0.369	+2.071	<.001	<.001	3	3
UCEC	RIC8A →	+0.300	+1.513	<.001	<.001	3	3
UCEC	THAP3 →	+0.241	+1.769	.001	.003	3	3
UCEC	PPP2R5B →	+0.311	+1.776	.002	.007	3	3
UCEC	ACOT7 →	+0.547	+2.779	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,314 associations by consensus.

CCDC7 by USP47 expression — UCEC

Explore this box plot interactively →