USP47

Across TCGA patient cohorts, USP47 mutation is significantly associated with the total protein of many other genes, with 66 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible USP47-associated genes across cancer lineages are GAPDH, TFRC, and Caspase-7-cleavedD198. Each is linked with USP47 in more than 3 cancer types. Because this analysis shows association rather than direction, both USP47-to-partner and partner-to-USP47 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, GAPDH grouped by USP47-low versus USP47-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (USP47→partner) and Y-score (partner→USP47) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	GAPDH →	+0.462	+2.087	.003	.004	3	4
UCEC	TFRC →	+0.446	+1.295	.003	.010	3	3
UCEC	Caspase-7-cleavedD198 →	+0.693	+1.894	<.001	.001	3	3
UCEC	EGFR_pY1068 →	-0.273	-1.906	<.001	<.001	3	2
UCEC	eIF4E →	+0.222	+1.906	<.001	<.001	3	2
UCEC	ERK2 →	+0.186	+1.777	<.001	.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 66 associations by consensus.

GAPDH by USP47 expression — UCEC

Explore this box plot interactively →