USP47

Across TCGA cell cohorts, USP47 mutation is significantly associated with the RNA expression of many other genes, with 14 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible USP47-associated genes across cancer lineages are TBC1D21, XKR3, and LRRD1. Each is linked with USP47 in more than 1 cancer types. Because this analysis shows association rather than direction, both USP47-to-partner and partner-to-USP47 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, TBC1D21 grouped by USP47-low versus USP47-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (USP47→partner) and Y-score (partner→USP47) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	TBC1D21 →	+0.010	+4.022	<.001	.006	3	1
LARGE_INTESTINE	XKR3 →	+0.056	+4.115	<.001	.001	3	1
LARGE_INTESTINE	LRRD1 →	+0.043	+3.453	<.001	.009	3	1
LARGE_INTESTINE	OR6Q1 →	+0.015	+4.022	<.001	.006	3	1
LARGE_INTESTINE	CD300H →	+0.036	+4.415	<.001	<.001	3	1
SKIN	MC3R →	+0.120	+2.621	.001	.008	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 14 associations by consensus.

TBC1D21 by USP47 expression — LARGE_INTESTINE

Explore this box plot interactively →