USP46-DT

Across TCGA pan-cancer cohorts, USP46-DT RNA is linked to patient survival in 22 of 34 cancer types, making it the most broadly survival-associated USP46-DT data layer.

The strongest signal is observed in uterine carcinosarcoma (UCS), where higher USP46-DT RNA is associated with better overall survival. In most high-consensus cancer types, elevated USP46-DT expression acts as an unfavorable survival marker, although some lineages such as UCS and KIRC show a favorable association.

UCS, KIRC, and LIHC are the cancer types where USP46-DT RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UCS	OS	Quartile	II,III,IV	0.865	0.265	.001	64	view →
KIRC	DFS	Median	All	0.776	0.483	<.001	52	view →
LIHC	DFS	Quartile	All	0.289	0.480	.001	44	view →
KIRP	DFS	Tertile	III,IV	0.117	0.484	.004	38	view →
THCA	OS	Median	II,III,IV	0.745	0.896	.004	23	view →
ESCA	DFS	Tertile	All	1.000	0.465	.008	18	view →
ACC	OS	Tertile	IV	1.000	0.329	.024	17	view →
READ	OS	Median	IV	0.819	0.479	.010	15	view →
BRCA	DFS	Median	III,IV	0.915	0.835	.015	12	view →
OV	OS	Tertile	IV	0.572	0.272	.006	12	view →
PRAD	OS	Tertile	All	1.000	0.969	.015	10	view →
COAD	DFS	Quartile	All	0.671	0.459	.023	7	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 22 lineages.

USP46-DT–UCS (OS)

Open the UCS breakdown →