USP42

Across TCGA pan-cancer cohorts, USP42 mass-spec protein is linked to patient survival in 4 of 34 cancer types, making it a survival-associated USP42 data layer compared with 26 for mass-spec protein and 9 for mutation status.

The strongest signal is observed in clear cell renal cell carcinoma (CCRCC), where higher USP42 mass-spec protein is associated with better disease-free survival. In most high-consensus cancer types, elevated USP42 expression acts as an unfavorable survival marker, although some lineages such as CCRCC and PDAC show a favorable association.

CCRCC, LUAD, and PDAC are the cancer types where USP42 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
CCRCC	DFS	Tertile	All	0.946	0.517	.001	51	view →
LUAD	DFS	Median	III,IV	0.353	0.744	.021	8	view →
PDAC	DFS	Median	All	0.749	0.267	.006	7	view →
HNSC	DFS	Quartile	III,IV	0.235	0.648	.009	6	view →

Pink = unfavorable, green = favorable. Showing the 4 strongest of 4 lineages.

USP42–CCRCC (DFS)

Open the CCRCC breakdown →