USP42

Across TCGA patient cohorts, USP42 mutation is significantly associated with the total protein of many other genes, with 66 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible USP42-associated genes across cancer lineages are Caspase-7-cleavedD198, 4E-BP1, and Cyclin-B1. Each is linked with USP42 in more than 3 cancer types. Because this analysis shows association rather than direction, both USP42-to-partner and partner-to-USP42 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Caspase-7-cleavedD198 grouped by USP42-low versus USP42-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (USP42→partner) and Y-score (partner→USP42) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Caspase-7-cleavedD198 →	+0.680	+2.267	<.001	<.001	3	4
UCEC	4E-BP1 →	+0.298	+2.807	<.001	.002	3	3
UCEC	Cyclin-B1 →	+0.832	+2.807	<.001	<.001	3	3
UCEC	eEF2 →	+0.318	+2.415	.004	.002	3	2
UCEC	FoxM1 →	+0.203	+1.836	.012	.001	3	2
UCEC	GAPDH →	+0.414	+2.222	.014	.009	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 66 associations by consensus.

Caspase-7-cleavedD198 by USP42 expression — UCEC

Explore this box plot interactively →