USP42

Across TCGA cell cohorts, USP42 mutation is significantly associated with the RNA expression of many other genes, with 398 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible USP42-associated genes across cancer lineages are OR4N4, OR4D6, and GRSF1. Each is linked with USP42 in more than 2 cancer types. Because this analysis shows association rather than direction, both USP42-to-partner and partner-to-USP42 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, OR4N4 grouped by USP42-low versus USP42-high in PANCREAS.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (USP42→partner) and Y-score (partner→USP42) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PANCREAS	OR4N4 →	+0.021	+5.000	.004	.006	3	2
OESOPHAGUS	OR4D6 →	+0.013	+4.906	<.001	.006	3	2
LUNG_NSCLC_LUAD	GRSF1 →	+0.460	+3.206	.003	.006	3	2
LUNG_NSCLC_LUAD	PDCL2 →	+0.206	+3.029	.001	.003	3	2
LUNG_NSCLC_LUAD	CD300LD →	+0.038	+2.777	.005	.004	3	2
SKIN	FOXE3 →	+0.063	+2.716	.008	.009	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 398 associations by consensus.

OR4N4 by USP42 expression — PANCREAS

Explore this box plot interactively →