USP40

Across TCGA pan-cancer cohorts, USP40 mass-spec protein is linked to patient survival in 3 of 34 cancer types, making it a survival-associated USP40 data layer compared with 24 for mass-spec protein and 7 for mutation status.

The strongest signal is observed in pancreatic ductal adenocarcinoma (PDAC), where higher USP40 mass-spec protein is associated with worse disease-free survival. In most high-consensus cancer types, elevated USP40 expression acts as an unfavorable survival marker, although some lineages such as CCRCC show a favorable association.

PDAC, CCRCC, and LSCC are the cancer types where USP40 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
PDAC	DFS	Median	II,III,IV	0.643	0.911	.003	35	view →
CCRCC	DFS	Tertile	II,III,IV	0.928	0.105	.006	30	view →
LSCC	DFS	Tertile	II,III,IV	0.851	1.000	.024	1	view →

Pink = unfavorable, green = favorable. Showing the 3 strongest of 3 lineages.

USP40–PDAC (DFS)

Open the PDAC breakdown →