USP40

Across TCGA cell cohorts, USP40 mutation is significantly associated with the RNA expression of many other genes, with 79 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible USP40-associated genes across cancer lineages are MIS18A, FAM47A, and FOXR2. Each is linked with USP40 in more than 1 cancer types. Because this analysis shows association rather than direction, both USP40-to-partner and partner-to-USP40 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MIS18A grouped by USP40-low versus USP40-high in STOMACH.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (USP40→partner) and Y-score (partner→USP40) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STOMACH	MIS18A →	+0.645	+3.070	.003	.008	3	2
SKIN	FAM47A →	+0.015	+3.684	<.001	.006	3	2
BLOOD_Leukemia	FOXR2 →	+0.200	+3.551	<.001	.009	3	2
PANCREAS	GYS2 →	+0.193	+4.237	<.001	.006	3	1
PANCREAS	GZMK →	+0.005	+4.614	<.001	.004	3	1
PANCREAS	DIPK1C →	+0.017	+4.491	.008	.003	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 79 associations by consensus.

MIS18A by USP40 expression — STOMACH

Explore this box plot interactively →