USP4

Across TCGA pan-cancer cohorts, USP4 mass-spec protein is linked to patient survival in 6 of 34 cancer types, making it a survival-associated USP4 data layer compared with 26 for mass-spec protein and 3 for mutation status.

The strongest signal is observed in glioblastoma multiforme (GBM), where higher USP4 mass-spec protein is associated with worse disease-free survival. In most high-consensus cancer types, elevated USP4 expression acts as an unfavorable survival marker, although some lineages such as COAD and LUAD show a favorable association.

GBM, COAD, and PDAC are the cancer types where USP4 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
GBM	DFS	Median	All	0.244	0.493	.006	15	view →
COAD	DFS	Median	III,IV	1.000	0.841	.041	12	view →
PDAC	DFS	Quartile	II,III,IV	0.319	0.507	.014	10	view →
LSCC	OS	Tertile	II,III,IV	0.631	0.906	.013	4	view →
LUAD	DFS	Tertile	II,III,IV	1.000	0.765	.033	3	view →
HNSC	DFS	Tertile	All	0.905	0.985	.040	1	view →

Pink = unfavorable, green = favorable. Showing the 6 strongest of 6 lineages.

USP4–GBM (DFS)

Open the GBM breakdown →